Genomic profiling of lower-grade gliomas uncovers cohesive disease groups: implications for diagnosis and treatment
Abstract Lower-grade gliomas (including low- and intermediate-grade gliomas, World Health Organization grades II and III) are diffusely infiltrative neoplasms that arise most often in the cerebral hemispheres of adults and have traditionally been classified based on their BUTTERBUR presumed histogenesis as astrocytomas, oligodendrogliomas, or oligo